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Iron controls T helper cell pathogenicity by promoting glucose metabolism in autoimmune myopathy.
Lai Y, Zhao S, Chen B, Huang Y, Guo C, Li M, Ye B, Wang S, Zhang H, Yang N. Lai Y, et al. Clin Transl Med. 2022 Aug;12(8):e999. doi: 10.1002/ctm2.999. Clin Transl Med. 2022. PMID: 35917405 Free PMC article.
Glucose uptake, T-cell proliferation and differentiation were evaluated and measured by flow cytometry. Human CD4(+) T-cells treated with iron chelators or Pfkfb4 siRNA were measured for glucose metabolism, proliferation and differentiation. ...Mechanistically, iron promot …
Glucose uptake, T-cell proliferation and differentiation were evaluated and measured by flow cytometry. Human CD4(+) T-cells treated with ir …
Prognostic Value of PFKFB3 to PFKFB4 mRNA Ratio in Patients With Primary Glioblastoma (IDH-Wildtype).
Kessler R, Fleischer M, Springsguth C, Bigl M, Warnke JP, Eschrich K. Kessler R, et al. J Neuropathol Exp Neurol. 2019 Sep 1;78(9):865-870. doi: 10.1093/jnen/nlz067. J Neuropathol Exp Neurol. 2019. PMID: 31369092
PFKFB3 mRNA levels were considerably higher than those of PFKFB4 in all analyzed tumors. IDH-wildtype glioblastomas showed lower PFKFB3 to PFKFB4 mRNA ratios (7.7:1) than IDH-mutant low-grade astrocytomas (36.5:1), indicating a dependency of the ratio on malignancy …
PFKFB3 mRNA levels were considerably higher than those of PFKFB4 in all analyzed tumors. IDH-wildtype glioblastomas showed lower PFKF …
RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival.
Goidts V, Bageritz J, Puccio L, Nakata S, Zapatka M, Barbus S, Toedt G, Campos B, Korshunov A, Momma S, Van Schaftingen E, Reifenberger G, Herold-Mende C, Lichter P, Radlwimmer B. Goidts V, et al. Oncogene. 2012 Jul 5;31(27):3235-43. doi: 10.1038/onc.2011.490. Epub 2011 Nov 7. Oncogene. 2012. PMID: 22056879
Interestingly, a number of genes identified are involved in metabolism, especially glycolysis, such as PDK1 and PKM2 and, most prominently PFKFB4. In vitro studies confirmed an essential role of PFKFB4 in the maintenance of brain CSCs. Furthermore, high PFKFB4 …
Interestingly, a number of genes identified are involved in metabolism, especially glycolysis, such as PDK1 and PKM2 and, most prominently …
Uncovering the Impact of Aggrephagy in the Development of Alzheimer's Disease: Insights Into Diagnostic and Therapeutic Approaches from Machine Learning Analysis.
Xu J, Gou S, Huang X, Zhang J, Zhou X, Gong X, Xiong J, Chi H, Yang G. Xu J, et al. Curr Alzheimer Res. 2023;20(9):618-635. doi: 10.2174/0115672050280894231214063023. Curr Alzheimer Res. 2023. PMID: 38141185
Based on the ROC(0.956). We identified five characteristic genes (PFKFB4, PDK3, KIAA0319L, CEBPD, and PHC2T) associated with AD immune cells and function. ...
Based on the ROC(0.956). We identified five characteristic genes (PFKFB4, PDK3, KIAA0319L, CEBPD, and PHC2T) associated with AD immun …
Autoinflammation in addition to combined immunodeficiency: SLC29A3 gene defect.
Çağdaş D, Sürücü N, Tan Ç, Kayaoğlu B, Özgül RK, Akkaya-Ulum YZ, Aydınoğlu AT, Aytaç S, Gümrük F, Balci-Hayta B, Balci-Peynircioğlu B, Özen S, Gürsel M, Tezcan İ. Çağdaş D, et al. Mol Immunol. 2020 May;121:28-37. doi: 10.1016/j.molimm.2020.02.014. Epub 2020 Mar 6. Mol Immunol. 2020. PMID: 32151906
RNA sequencing studies revealed decreased expression of NLR Family Caspase Recrument-Domain Containing 4(NLRC4), 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4(PFKFB4), serine dehydratase(SDS), heparan sulfate(Glucosamine) 3-O-sulfotransferase 1(HS3ST1), neutral ch …
RNA sequencing studies revealed decreased expression of NLR Family Caspase Recrument-Domain Containing 4(NLRC4), 6-phosphofructo-2-kinase/fr …
[EXPRESSION OF PFKFB, HK2, NAMPT, TSPAN13 AND HSPB8 GENES IN PEDIATRIC GLIOMA].
Minchenko DO, Novik YE, Maslak HS, Tiazhka OV, Minchenko OH. Minchenko DO, et al. Lik Sprava. 2015 Oct-Dec;(7-8):43-8. Lik Sprava. 2015. PMID: 27491149 Ukrainian.
RNA was isolated from glioma tissue and corresponding non-malignant tissue counterparts and PFKFB1, PFKFB2, PFKFB3, PFKFB4, HK2, NAMPT, TSPAN13, and HSPB8 gene expressions were studied by quantitative polymerase chain reaction. ...More significant changes were demonstrated …
RNA was isolated from glioma tissue and corresponding non-malignant tissue counterparts and PFKFB1, PFKFB2, PFKFB3, PFKFB4, HK2, NAMP …
Absolute expressions of hypoxia-inducible factor-1 alpha (HIF1A) transcript and the associated genes in chicken skeletal muscle with white striping and wooden breast myopathies.
Malila Y, Thanatsang K, Arayamethakorn S, Uengwetwanit T, Srimarut Y, Petracci M, Strasburg GM, Rungrassamee W, Visessanguan W. Malila Y, et al. PLoS One. 2019 Aug 8;14(8):e0220904. doi: 10.1371/journal.pone.0220904. eCollection 2019. PLoS One. 2019. PMID: 31393948 Free PMC article.
Transcript abundances of genes encoding 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4), lactate dehydrogenase-A (LDHA), and phosphorylase kinase beta subunit (PHKB) were increased in heavy-WS but decreased in heavy-WS+WB. ...
Transcript abundances of genes encoding 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4), lactate dehydrogenase-A (LDHA …